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1.    Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 Feb 4.
2.     寮电埥绛?灏忕窗鑳炶偤鐧屽€嬮珨鍖栨不鐧傞€插睍[J].涓湅鑵槫鑷ㄥ簥,2017,44(12):571-576.
3.     Gaspar LE, et al. Small-cell lung cancer: prognostic factors and changing treatment over 15 years. Clin Lung Cancer. 2012 Mar;13(2):115-22.
4.     Pesch B, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012 Sep 1;131(5):1210-9.
5.     Kalemkerian GP. Small Cell Lung Cancer. Semin Respir Crit Care Med. 2016 Oct;37(5):783-796.
6.     Stinchcombe TE, et al. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist. 2010;15(2):187-95.
7.     Lally BE, et al. Small cell lung cancer: have we made any progress over the last 25 years? Oncologist. 2007 Sep;12(9):1096-104.
8.     Socinski MA, et al. Phase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with extensive-stage small-cell lung cancer. J Clin Oncol. 2009 Oct 1;27(28):4787-92.

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